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BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.

Acosta-Medina, Aldo A; Kemps, Paul G; Zondag, Timo C E; Abeykoon, Jithma P; Forma-Borst, Jelske; Steenwijk, Eline C; Feijen, Elizabeth A M; Teepen, Jop C; Bennani, N Nora; Schram, Susan M; Shah, Mithun V; Davidge-Pitts, Caroline; Koster, Matthew J; Ryu, Jay H; Vassallo, Robert; Tobin, W Oliver; Young, Jason R; Dasari, Surendra; Rech, Karen; Ravindran, Aishwarya; Cleven, Arjen H G; Verdijk, Robert M; van Noesel, Carel J M; Balgobind, Brian V; Bouma, Gerrit Joan; Saeed, Peerooz; Bramer, Jos A M; de Groen, Ruben A L; Vermaat, Joost S P; van de Sande, Michiel A J; Smit, Egbert F; Langerak, Anton W; van Wezel, Tom; Tonino, Sanne H; van den Bos, Cor; van Laar, Jan A M; Go, Ronald S; Goyal, Gaurav; van Halteren, Astrid G S.

Blood ; 142(18): 1570-1575, 2023 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-37595284

RESUMEN

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

Asunto(s)

Histiocitosis de Células de Langerhans , Neoplasias Primarias Secundarias , Humanos , Adulto , Neoplasias Primarias Secundarias/epidemiología , Neoplasias Primarias Secundarias/genética , Proteínas Proto-Oncogénicas B-raf/genética , Estudios Retrospectivos , Incidencia , Histiocitosis de Células de Langerhans/epidemiología , Histiocitosis de Células de Langerhans/genética , Histiocitosis de Células de Langerhans/patología , Mutación

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